![]() ![]() ![]() Recently, plant-derived photosensitive modules have been engineered into STIM1 to generate genetically encoded Ca 2+ actuators (GECA) 5, 8, 9, 10, 11, thereby enabling remote and noninvasive control of CRAC channel-mediated Ca 2+ entry into cells 12, 13, 14, 15. Aberrant STIM1–ORAI1 signaling has been intimately linked to immunoinflammatory disorders, myopathy, tumorigenesis, and neurodegenerative diseases, making the CRAC channel a potential therapeutic target 5, 6, 7. The prototypical Ca 2+ release-activated Ca 2+ (CRAC) channel, composed of ORAI1 and the stromal interaction molecule 1 (STIM1), constitutes an important Ca 2+ entry route in mammalian cells 1, 2, 3, 4.
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